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Prurigo nodularis (PN) is a skin disease characterised by pruritic (itchy) nodules which usually appear on the arms or legs. Patients often present with multiple excoriated lesions caused by scratching .
The cause of prurigo nodularis is unknown, although other conditions may induce PN. PN has been linked to an autoimmune condition, liver disease and T cells. Systemic pruritus has been linked to cholestasis, thyroid disease, polycythaemia rubra vera, uraemia, Hodgkins disease, HIV and other immunodeficiency diseases. Internal malignancies, liver failure, renal failure, and psychiatric illnesses may induce PN, although more recent research has refuted a psychiatric cause for PN
Prurigo nodularis is a skin condition characterized by the presence of firm, itchy nodules on the skin. While the condition is not life-threatening, it can be chronic and significantly impact a person’s quality of life.
Here are some of the risks associated with prurigo nodularis:
Chronic Itch: Prurigo nodularis can cause intense itching that can be chronic, leading to skin damage due to constant scratching. Itching can also lead to sleep disturbances, anxiety, and depression.
Infection: Scratching the nodules can lead to breaks in the skin, increasing the risk of bacterial infections. If left untreated, infections can spread and cause more severe skin problems.
Scarring: The constant scratching of the nodules can lead to scarring, which can be permanent and disfiguring.
Reduced Quality of Life: Prurigo nodularis can significantly impact a person’s quality of life, affecting their ability to work, sleep, and engage in daily activities. The condition can also cause emotional distress, leading to anxiety and depression.
Side Effects of Treatment: Treatment for prurigo nodularis may include topical or oral medications, light therapy, or surgery. However, these treatments can have side effects, and some may be ineffective.
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